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L-asparaginase

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L-asparaginase

Sanzyme Biologics, is specialize in the manufacture of L-asparaginase for Active Pharmaceutical Ingredients (API) in a state-of-the-art facility for bulk orders. Our commitment to quality and compliance ensures that our products meet the highest standards set by CGMP and WHO GMP.

Product                         L-asparaginase for API

CAS Number –                    9015-68-3

Source –                               E.coli

Molecular Mass –             31.73kDa

pH                                          6.5-7.5

EC Number:                        3.5.1.1

High Purity and Consistency
  • L-Asparaginase is produced in a controlled environment.
  • Free from animal-derived contaminants.
  • Purity NLT 97%
Activity and Specificity:
  • Maintains high Specific activity of NLT 250 units/mg.
Stability
  • Stable at recommended storage conditions for 36 months.
  • Available as lyophilized powder.
Scalability
  • Manufactured in compliance with WHO-Good Manufacturing Practices (GMP), ensuring reliability for commercial applications.

Applications:

Acute Lymphoblastic Leukemia (ALL)
  • L-Asparaginase is a critical component of multi-agent chemotherapy regimens for ALL.
  • It is used during the induction and consolidation phases of treatment to achieve remission and prevent relapse.
Other Malignancies
  • L-Asparaginase has been explored in the treatment of other cancers, such as non-Hodgkin's lymphoma, with varying degrees of success.
Therapeutic Enzyme Replacement
  • Beyond oncology, L-Asparaginase has potential applications in enzyme replacement therapies for metabolic disorders where asparagine accumulation is a concern.
Food applications
  • L-Asparaginase is an enzyme that can be used in food to reduce acrylamide levels in fried potato products, bakery products, and coffee.
  • L-Asparaginase can reduce acrylamide levels in fried potato chips by 55–96%. It works by hydrolyzing L-asparagine, a precursor to acrylamide, into aspartic acid

To learn more about our L-Asparaginase for API or to discuss your specific requirements, please get in touch with our team today.

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